In: Anatomy and Physiology
Questions 19-20
19. Which of the following factors INCREASES hemoglobin’s affinity for oxygen? [MARK ALL THAT APPLY]
a. decreased [H+ ] b. decreased temperature c. decreased PO2 d. decreased pH e. increased PCO2
20. You discover a new mutation in the gene coding for carbonic
anhydrase. You observe that patients with this mutation
exhibit:
a. less buffering capacity of the blood
d. higher PCO2 levels in blood
b. less bicarbonate [HCO3-] concentration in blood
e. Hb has a lower affinity for O2 than normal
c. any of these could indicate a problem with carbonic anhydrase
19. The binding affinity of hemoglobin to oxygen drpends on
factors such as partial pressure of oxygen, partial pressure of
CO2, pH and temperature.
Increase in partial pressure of oxygen and increase in pH increase
the binding capacity of hemoglobin to oxygen.
Decrease in partial pressure of CO2 and decrease in temperature
also increases hemoglobin affinity for oxygen.
Decrease in H+ ions results in high pH which increases hemoglobin
binding for oxygen.
So the correct option is a. decreased [H+ ] b. decreased
temperature
20. Carbonic anhydrase is an enzyme found in RBC which helps in
conversion pf CO2 to carbonic acid and bicarbonate ions. It helps
regulate the blood pH and pCO2 levels in blood.
Low buffering capacity of the blood, high PCO2 levels in blood, low
bicarbonate [HCO3-] concentration in blood and decreased affinity
of Hb for O2 implies towards a problem with carbonic
angydrase.
So the correct option is (c. ) any of these could indicate a
problem with carbonic anhydrase