Question

Once you view the video-link below, post a critique about the potential of using anti-quorum sensing molecules as weapons against bugs that are resistant to traditional antibiotics (250 WORDS -- TYPED -- NO DIAGRAMS).

https://www.ted.com/talks/bonnie_bassler_on_how_bacteria_communicate?language=en

Answer 1

Evaluating in a theoretical and analytical way we can dig dipper into the field of medicine. From the Bonnie Bassler talk, it is clear about the bacterial census part. The communication mechanism is way simpler if just been looked through the chemical molecules similarity part. In the real-time, cellular environment is much more complex. The suggestion from the talk is centered around the intra-species as well as inter-species communication.

Quorum sensing is a natural phenomenon among the most thriving organisms on this planet. While we talk about to stop their spread of lethal chemicals and their virulent actions, we also need to focus on the good ones. Most vibrant and symbiotic natured ones are also affected by their communication as well as our activity through antibiotic.

The coordinated defense and mutual talk of microorganisms are of main focus.

Coming to antibiotic molecules, these are the most potent weapons till the 20^th century. As we are progressing in this 21^st century, we are struck by the superbug and another kind of defense responses from bacteria. Looking for fundamental approach would tell us their mechanisms are altered in their cellular environment. Hence the hand-in-hand use of anti-quorum sensing molecule (AQSM), which is focused on binding like natural receptors, would be of good value.

AQSM are neither being engulfed by the bacteria nor being detected as foreigners. Thus their specificity would go in a long run, replacing the natural stimulators from bacteria. We are to evaluate the natural remedial medicines likely from plant sources to replace most of the antibiotic use as well. They have been proven to be good with no or minimum side effects.