Question

In: Chemistry

which of the following statements about the charge distribution on the amino acid glutamate is incorrect...

which of the following statements about the charge distribution on the amino acid glutamate is incorrect ?

glutamate has three different ionizable groups

at a very low pH, the most abundant form of glutamate will have net charge of +1

at a very high pH the most abundant form of glutamate will have a net charge of -2

at a pH of aprox. 3.2 glutamate will not contain any charged groups

all of the above are correct

Solutions

Expert Solution

Ans. Statements C and D are incorrect.

Incorrect statement C = At pH of approx.. 3.2 glutamate will not contain any charged groups. At this pH, the N-terminal amine group has a +0.99 (=+1.0 approx.) unit charge, the C-terminal carboxyl group has (-) 0.91 unit charge. So, this statement is incorrect.

D = All of the above statements are correct. Statement C is incorrect.

# Glutamate has three ionizable groups- the N-terminal amine group, the C-terminal carboxyl group, and the R-group.

# As calculated-

            At very low pH, say 1.00, it has a net charge of +1.

            At very low pH, say 14.00, it has a net charge of -2.

So, statements A, B and C are true.


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