- which type of abnormal lipoprote in Familial hypertriglyceridemia. - whats the processes lead to Hypertriglyceridemia...

- which type of abnormal lipoprote in Familial hypertriglyceridemia.

- whats the processes lead to Hypertriglyceridemia

- Compare the metabolic pathway of that lipoprotein in both normal and patient with Familial hypertriglyceridemia . use a figures

- whats difference between Familial hypertriglyceridemia disease & Familial mixed hyperlipedemia

- Fibrates used as modulator for fat metabolism, explain the mechanism of action

Expert Solution

As per Frederickson classification

Type 4 and Type 5 Hyperlipoproteinaemia with Triglyceridaemia fall into famililial Hypertrigyceriademia

Type 3 is Familial mixed Hyperlipidaemia
Also known as Remnant removal disease and Broad B disease

Clinical features
1.Milky white plasma
2. Lipaemic retinitis
3.Eruptive xanthomas
4.Increased Triglycerides leads to pancreatitis and abdominal pain

Fibrates as modulator for fat metabolism MOA- Act by avtivating LPL lipoprotein lipase by activating a nuclear receptor PPAR alpha ( peroxisome propiferator activated receptor alpha).
Major effect is to reduce Trigycerides contained in VLDL very low density lipoprotein and to increase HDL high density lipoprotein .
Eg Fenofibrate is prodrug with longest half life .It has maximum LDL cholesterol lowering action .Fibrates are drug of choice in Type 3 and type 4 hyperlipoproteinaemia .

New research - Gene therapy Lipogene Tiparvivec

Sydney Mullin answered 1 year ago

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- which type of abnormal lipoprote in Familial hypertriglyceridemia. - whats the processes lead to Hypertriglyceridemia...

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