Explain why there can be no net glucose production from fatty acids and acetylCoA, although carbons...

Explain why there can be no net glucose production from fatty acids and acetylCoA, although carbons from acetylCoA can end up in glucose.

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Expert Solution

In animals, metabolism of fatty acids doesn't directly give rise to lucose. Fatty acids are broken down two carbons at a time and they turn into acetyl units of acetyl coA. Now, there is no enzyme present that could conversation acetyl coA into any substance, like Pyruvate, that could enter the glucogenesis pathway that would result in the production of glucose. However, this acetyl coA enters Kreb's cycle that results in oxaloacetate. The oxaloacetate is on the glucogenesis pathway. However, OAA production is equal to OAA consumption and there is no net conversion of Acetyl coA into OAA. But some carbons of Acetyl coA are present in glucose.

queen_honey_blossom answered 1 year ago

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