Question

In: Chemistry

fatty acids with an odd number of carbons are modified by carboxylation of propionyl CoA to...

fatty acids with an odd number of carbons are modified by carboxylation of propionyl CoA to ultimately generate the 4 carbon TCA intermediate_____ a. citric acid b. succinyl CoA c. Fumaric acid d. oxalic acid CoA e. Acetyl CoA

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Expert Solution

Dear friend your answer is                 b. succinyl CoA

Please see below for proof

Odd-numbered fatty acids
Fatty acids with odd numbers of carbons are found in some marine animals, in many herbivores, in microorganisms, and in plants. These fatty acids are subjected to ?-oxidation in the same way as fatty acids with even numbers of carbons. However, the final ?-oxidation spiral results in the production of the three-carbon compound propionyl-CoA, which cannot be metabolized in the same way as acetyl- CoA. Instead, propionyl-CoA is converted to succinyl-CoA, a TCA cycle intermediate, via a three enzyme pathway.

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