In: Biology
name and describe 2 different cellular locomotion
Cytoskeletal model
Leading edge;
here, is rapid actin polymerisation at the cell's front edge and has led to the hypothesis that formation of actin filaments "push" the leading edge forward and is the main motile force for advancing the cell's front edge.
In addition, cytoskeletal elements are able to interact extensively and intimately with a cell's plasma membrane.
Membrane flow model;
the front of the migration is the site at which the membrane is returned to the cell surface from internal membrane pools at the end of the endocytic cycle. This has led to the hypothesis that extension of the leading edge occurs primarily by addition of membrane at the front of the cell.
If so, the actin filaments that form at the front might stabilize the added membrane so that a structured extension, or lamella, is formed rather than a bubble-like structure (or bleb) at its front.
For a cell to move, it is necessary to bring a fresh supply of "feet" (proteins called integrins, which attach a cell to the surface on which it is crawling) to the front. It is likely that these feet are endocytosed toward the rear of the cell and brought to the cell's front by exocytosis, to be reused to form new attachments to the substrate.