Question

Each of the following is associated with haemophilia A or B EXCEPT:

Select one:

a. Recurrent haemarthroses in a young boy

b. Normal prothrombin time

c. Prolonged prothrombin time and normal activated partial thromboplastin time

d. Prolonged activated partial thromboplastin time

e. A factor IX level below 5%

Answer 1

The right option is: (C) prolonged prothrombin time and normal activated partial thromboplastin time

Explanation:

In hemophilia all below happens

recurrent haemarthroses (bleeding into a joint)

Normal prothrombin time (see in explanation)

prolong APTT

Factor  IX is too low

Concept:

Hemophilia disease causes a bleeding problem in the body due to impairment of blood clotting factor. There are two types:

• hemophilia A — a deficiency of factor VIII
• hemophilia B — a deficiency of factor IX

Hemophilia screening tests

Blood tests are used to determine that the blood is clotting properly or not.

Complete blood count (CBC)

This measures the amount of hemoglobin, the number and size of RBCs, WBC, and platelets in the blood.

CBC results are normal in people with hemophilia, but a decrease in the number of hemoglobin and RBCs in the case of bleeding.

Activated partial thromboplastin time (APTT) test

This test measures the tame taken in blood clotting formation of factors VIII, IX, XI, and XII. It will take a longer time to clot if any factor concentration is two low or absent. The hemophilia A or hemophilia B shows a longer clotting time in APTT.

Prothrombin time (PT) test

This test also measures the time taken in a blood clotting to the formation. But It measures the clotting ability of factors I, II, V, VII, and X. If any factors are too low in concentration, it takes longer than normal for clotting.

The PT results are normal in hemophilia A or hemophilia B since these conditions are caused by defects in factors VIII and IX, respectively.

Fibrinogen test

Fibrinogen (clotting factor I) test measure the ability of the patient’s blood clotting formation.