Is it likely that glycosylated threonine residues will be found on proteins located in the lumen...

Is it likely that glycosylated threonine residues will be found on proteins located in the lumen of the endoplasmic reticulum? Explain

Expert Solution

SOLUTION- glycans serves a variety of structural and functional roles in the membrane and secreted proteins. the majority of proteins synthesized in the rough endoplasmic reticulum undergo glycosylation. it is an enzyme directed site-specific process, as opposed to a non -enzymatic chemical reaction of glycation. glycation is also present in the cytoplasm and nucleus as the o-glcnac modification.

PROTEIN GLYCOSYLATION is an enzyme directed chemical reaction that takes place in the ER(endoplasmic reticulum) and in the Golgi apparatus body of the cell. general glycosylation within the endoplasmic reticulum helps with folding and glycosylation in the Golgi body tells a protein where to go.it is a process by which a carbohydrate is covalently attached to a target macromolecule, typically proteins and lipids.

glycosylation starts at the endoplasmic reticulum during protein synthesized in the ribosome moreover the covalently binding of glycans to the protein surface may inherently enhance the thermal and kinetic stability of proteins

precursor glycan synthesis begins on the cytosolic face of the endoplasmic reticulum and is completed after the structure is flipped into endoplasmic reticulum lumen

thanks

gladiator answered 1 year ago

A.) Are glycosylated proteins found in the mitochondria? Why or why not? B.) Please explaib why...

A.) Are glycosylated proteins found in the mitochondria? Why or why not? B.) Please explaib why integrak membrane proteins are only found to be glycosylated on the extracelluar surface of the protein.

The activity of retinoblastoma protein (Rb) is regulated primarily by phosphorylation at various serine/threonine residues. Specific...

The activity of retinoblastoma protein (Rb) is regulated primarily by phosphorylation at various serine/threonine residues. Specific patterns of pRb phosphorylation generate pRb conformational variants that mediate distinct protein-protein interactions. In an experimental cell system with a mutation in the Rb gene that encodes alanine rather than serine, which is phosphorylated in the wild-type Rb, you observe that the cell is unable to enter into the cell cycle. What this observation suggest and how do you design an experiment to substantiate...

1) What types of glycosylation occur in ER vs. Golgi? 2) Why are proteins glycosylated? 3)...

1) What types of glycosylation occur in ER vs. Golgi? 2) Why are proteins glycosylated? 3) What types of export occur from the Golgi? - Under what circumstances are coat proteins used? And how does that help?

What kind of interaction can threonine and asparagine form? Would this interaction be likely to form...

What kind of interaction can threonine and asparagine form? Would this interaction be likely to form on the surface of a protein? Why or why not? What role does this interaction play in protein stability?

Residues such as valine, leucine, isoleucine, methionine and phenylalanine are often found in the interior of...

Residues such as valine, leucine, isoleucine, methionine and phenylalanine are often found in the interior of proteins, while arginine, lysine, aspartic acid and glutamic acid are often found on the surface. Suggest a reason for this. Where would you expect to find glutamine, glycine and Alanine?

In the active site of an enzyme, are Val and Ala residues found? True or false?

You study a serine/threonine protein kinase, which is likely involved in the regulation of actin dynamics....

You study a serine/threonine protein kinase, which is likely involved in the regulation of actin dynamics. You have good knowledge about the kinase (such as its kinase domain information and which residues are catalytic sites etc). You found a RhoGEF by yeast two-hybrid screening using the kinase as bait. Further, through co-immunoprecipitation assay, you confirmed that the kinase specifically interacts with the RhoGEF. Since RhoGEF is well known to regulate actin oligomerization, you expect that the protein might provide an...

You study a serine/threonine-protein kinase, which is likely involved in the regulation of actin dynamics. You...

You study a serine/threonine-protein kinase, which is likely involved in the regulation of actin dynamics. You have good knowledge about the kinase (such as its kinase domain information and which residues are catalytic sites etc). You found a RhoGEF by yeast two-hybrid screening using the kinase as bait. Further, through co-immunoprecipitation assay, you confirmed that the kinase specifically interacts with the RhoGEF. Since RhoGEF is well known to regulate actin oligomerization, you expect that the protein might provide an important...

A double stranded DNA molecule was found to have a total of 10,000 A+T base residues...

A double stranded DNA molecule was found to have a total of 10,000 A+T base residues and 14,000 G+C residues. Analysis of one of the strands of DNA showed that it had 3,000 A and 4,000 C residues. What is the number of T and G base residues on this strand?

Glycine residues occur in a higher percentage in proteins than any other amino acid. Suggest two reasons...

Glycine residues occur in a higher percentage in proteins than any other amino acid. Suggest two reasons why.

Question