Question

Efficient oncogenic transformation of rodent cells:

a. blocks DNA replication

b. requires a mutation in at least 3 or more proto-oncogenes

c. requires a mutation in one protooncogene

d. inhibits cell cycle

e. lengthens G2 phase of the cells

Answer 1

Ans(b) requires a mutation in atleast 3 or more protooncogenes. Because, if the three protooncogenes mutant are dysregulated inside the cell. Then, the potential for the conversion into oncogenic transformed will be very efficient.

Rest all the options are incorrect.

Blocking DNA replication is not correct because it will not allow the cell to divide and cell won't be transformed.

Require a mutation in one protooncogenes is not a good idea because this Mutation won't assure that cell will become oncogenic. In many experiment it was well established that a single Mutation is not sufficient to drive cells towards oncogenic because cell have many mechanism to overcome.

Inside cell delaying G2 phase is also not a good idea because it may leads trigger apoptosis.

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