Question

You will be assigned tetracycline an antibiotic to focus your discussion on. Please answer the following questions about your assigned antibiotic.

tetracycline

• How does it kill bacteria?
• Is your antibiotic selectively toxic? Please explain your answer, including the definition of selective toxicity.
• How could bacteria become resistant to your antibiotic? Your answer should include the concepts of mutation and natural selection.
• What are some actions we, as a society, can take to limit antibiotic resistance?
• For your assigned antibiotic, describe an experiment that you could use to determine if a bacterial sample taken from a person was resistant to your antibiotic. Be sure to describe all steps of the experiment including your independent, dependent, and control variables.
• Initial discussion posts should have a minimum word length of 150 words.

Answer 1

Tetracyclines are obtained from the various pieces of streptomycin bacteria by fermentation technology

tetracycle antibiotics processes broad spectrum of activity of all known-antimicrobial agent

they kill bacteria by involving in inhibition  of  protein synthesis steps involved in killing are :

*Tetracyclines

*Taken up by active transport into bacteria

  *binds to 30 S ribosomal subunit

*Complete with and prevent binding to the tRNA to a site

*inhibit protein synthesis

*bacterial static

Selectively have some toxic effects of

1.renal toxicity : renalfailure increaseed level of nitrogen due to anti-anabolic effect of tetracycline
2. photo toxicity :skin reaction dermatitis on exposure to sun.
3.hepatotoxicity:large doses of tetracycline may result in jaundice.

Many organisms have now become resistant Moreover the organisms majorly develop resistance to many other antibiotics because the genes that control the distance to tetracyclines also influence the resistance to many other antibiotics resistance is exhibited as :

1.Decreased uptake of efflux of the antibiotic from the bacterium

2.Displacing tetracyclines from the binding site, that is the target ribosome

3.Elaborating enzymes that in activate tetracyclines

Cross-resistance among different tetracyclines is also noted .