Which of the following directly or indirectly results from an increase in action potential frequency/number in...

Which of the following directly or indirectly results from an increase in action potential frequency/number in serotonergic neurons?

	a.	Greater production of BH4
	b.	Greater production of the first unique synthetic protein in these neurons
	c.	Increase in the affinity of BH4 of the first unique synthetic enzyme in these neurons
	d.	End-product inhibition

Expert Solution

OPTION 4

That is end product inhibition..

Serotonin released within the dorsal raphe nucleus (DR) induces feedback inhibition of serotonin neuron activity and consequently regulates mood-controlling serotonin release throughout the forebrain. Serotonin packaged in vesicles is released in response to action potentials by the serotonin neuron soma and terminals, but the potential for release by dendrites is unknown . Serotonin release in the dorsal raphe nucleus (DR) activates somatodendritic 5-HT1A autoreceptors, which inhibit serotonin neuron activity and the resultant release from terminals. This autoregulation is involved in responses to stress and the delayed efficacy of selective serotonin reuptake inhibitor (SSRI) antidepressants

gladiator answered 2 years ago

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