Research in cell biology and metabolism has progressed due to the discovery of molecules that artificially...

Research in cell biology and metabolism has progressed due to the discovery of molecules that artificially stimulate or inhibit glucagon/epinephrine and insulin signaling pathways. Let’s say you are working in a lab cataloging the effects of a library of small molecules on these pathways and have a “hit” on molecule 1stAVNGR. Preliminary data on molecule 1stAVNGRindicates that the cardiac isoform of PFK2/FBPase2 is doubly phosphorylated when this molecule is present at micromolar concentrations in cell cultures.

A. In consideration of the data presented in this problem what would be the expected effect of molecule 1stAVNGRon glycolytic flux in a culture of cardiac myocytes? Explain your reasoning?

B.Finally, if molecule 1stAVNGRwere infused into a culture of hepatocytes what would be the expected effect on glycolytic flux in these cells? Explain your reasoning.

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gladiator answered 1 year ago

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