Question
In: Chemistry
synthesize 3-benzyl-2-phenylhexanal using an aldol condensation followed by conjugate addition of a gilman reagent
synthesize 3-benzyl-2-phenylhexanal using an aldol
condensation followed by conjugate addition of a gilman
reagent
Solutions
Expert Solution
Answer –
From the aldol condensation followed by a conjugate addition of a Gilman reagent there is need to synthesis of 3-benzyl-2-phenylhexanal
In the aldol condensation there is formed ?, ? unsaturated carbonyl compound when two carbonyl compound reacted to each other in presence of strong base.
When we reacting the two molecules of 2-phenylacetaldehyde in presence of base so there is formed (Z)-2,3-diphenylacrylaldehyde.
When Gilman reagent is reacting with (Z)-2,3-diphenylacrylaldehyde reacting then there is formed 3-benzyl-2-phenylhexanal. Gilman reagent is the combination of Li and Cu reagent. So when we reacted Gilman reagent (CH3CH2CH2)2CuLi with (Z)-2,3-diphenylacrylaldehyde in presence of acid then there is added propyl group to 1,2 to ?, ? unsaturated carbonyls and formed 3-benzyl-2-phenylhexanal as follow –
queen_honey_blossom answered 1 year agoRelated Solutions
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