Write a report style introduction to overlap-layout-consensus for fragment assembly (roughly 150 words).

Expert Solution

Overlap-layout-consensus for fragment assembly (OLC)

Introduction:-

Overlap–layout–consensus genome assembly algorithm (OLC):-
In Genomics, Overlapping regions are identified. Each read is graphed as a node and the overlaps are represented as edges joining the two nodes involved. The algorithm determines the best path through the graph (Hamiltonian path). Redundant information (i.e., unused nodes and edges) is discarded. This process is carried out multiple times and resulting sequences are combined to give the final consensus sequence that represents the genome.
In the DNA sequences, it is used for unresolvable repeats by essentially leaving them out fragments are contigs (short for contiguous)Unresolvable repeats break the assembly into a fragment.
we follow 3-steps in this algorithm.
Overlap ---> Build overlap graph ---> Finding overlaps.
Layout ---> Bundle stretches of the overlap graph into contigs.
Consensus ---> Pick most likely nucleotide sequences for each contig.
This is how we will use this algorithm in Genomics.

Thank You...!

venereology answered 1 year ago

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