Question

1. Using the sequence below give an example of an insertion, deletion, SNP, inversion, and translocation.

3’-ATTCGGCCAGTTAGCCGATG-5’

Answer 1

Insertion- It is the type of mutation where one or more bases are inserted or added. It causes frameshift mutation leading to change in the total amino acid sequences from the base where insertion has occured

Normal gene- 3’-ATTCGGCCAGTTAGCCGATG-5’

Insertion mutation- 3'-ATTCGGCCATAGTTAGCCGATG-5'

Deletion- It is the mutation where one or more basepair is deleted from the original sequence. It also causes frameshift mutation

Normal gene- 3’-ATTCGGCCAGTTAGCCGATG-5’

Deletion mutation- 3'-ATTCGGCAGTTAGCCGATG-5'

SNP-Single Nucleotide Polymorphism is the change in single base sequence in the genome between species which is passes through generations. they are genetic biomarkers

Normal gene- 3’-ATTCGGCCAGTTAGCCGATG-5’

SNP- 3'- ATTCGGCCAATTAGCCGATG-5'

Inversion mutation- It is the reversal of some part of the sequences of the gene

Normal gene- 3’-ATTCGGCCAGTTAGCCGATG-5’

Inversion mutation-3'-ATTCGCCCGATTAGCCCATG-5'

Translocation mutation- It is the transfer or movement of few bases from sequence of one gene to another gene sequence

Normal gene- 3’-ATTCGGCCAGT TAGCCGATG-5’

These mutations can cause genetic diseases.

Consider another gene- 3'- CAGGTTAGC TACTAATA-5'

Translocation mutation- 3'-ATTCGGCCAGTTACTAATA-5' AND 3'-CAGGTTAGCTAGCCGATG-5'