Question

IMMUNOLOGY QUESTION.

Give the mechanism of action and the result for each of the following therapeutic agents used to treat type I hypersensitivity reactions.

a) Antihistamines

b) cromolyn sodium

c) theophylline

d) epinephrine

e) cortisone

I asked this question before and it did not get fully answered. Please do not answer if you cannot answer the whole question. It is only one question.

Answer 1

a) Antihistamines are therapeutic drugs which are used against allergies.The main mechanism is by binding to the histamine receptors of the mast cells,smooth muscles in stomach etc...The result of this binding is that it prevent the histamine molecules from binding thus acting as a inverse agonist.

b)cromolyn sodium is used prevent the release of substances that causes inflammation.It works by preventing the mast cells from releasing histamine as result it prevents allergy symptoms

c).Theophylline is used in the therapy for respiratory diseases like asthma.It inhibits the leukotriene synthesis and reduces inflammation and as a result reduces the innate immunity.

d)Epinephrine as a medication is used to treat cardiac arrest,asthma and anaphylaxis.It acts as alpha 1 receptor to increase vasoconstriction,increased peripheral vascular resistance,and decreased mucosal edema.

e)Cortisone helps to decrease swelling and inflammation in the body.It also works by stopping the release of histamine as a result stops from having a immune response.