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A pharmaceutical company has found a new compound D-1000 that is a promising treatment for type...

A pharmaceutical company has found a new compound D-1000 that is a promising treatment for type 1 diabetes.  Your job is to determine if it is a mutagen.  You use two histidine auxotrophic S. typhimurium strains to determine the mutagenic potential of this chemical. TA1535 contains a T to C missense mutation in the his gene, leading to a leucine to proline amino acid substitution. TA1538 has a deletion of 1 base pair C in the his gene, which causes a -1 bpframeshift mutation.

Draw what you would expect your results to look like graphically if D-1000 acts as a mutagen only after metabolism and it acts by causing indel type mutations.

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gladiator answered 1 year ago
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