A son is born with Kleinfelter's syndrome and hemophilia. His father was normal and his mother...

A son is born with Kleinfelter's syndrome and hemophilia. His father was normal and his mother was a carrier for the recessive X-linked blood clotting disorder. What occurred in meiosis to produce this genetic outcome?

a. Nondisjunction in meiosis I of the mother

b. Nondisjunction in meiosis II of the father

c. Nondisjunction in either meiosis I or meiosis II of the father

d. Nondisjunction in meiosis II of the mother

e. Nondisjunction in meiosis I of the father

Expert Solution

Ans: Kleinfelter's syndrome is a disorder which occur in male and in which they have an extra X chromosome. Now both mother and father can be the donor of the extra X chromosome. Now as it is given in the question that the son along with the syndrome also suffer from hemophilia and hemophilia is a X-linked recessive disorder. Now it is also given in the question that the mother a carrier of hemophilia and let's consider her genotype Xxr where xr is representing allele for hemophilia and father is normal for this disorder and let's consider his genotype xx which means that if the non disjunction occur in mother and she will be the carrier of extra X chromosome then the genotype of the son is XxrY and he will also be the carrier of hemophilia but do not suffer from hemophilia. Now if father will be the carrier of extra X chromosome and non disjunction occur in father's than the genotype of the son is xxrY and he will be suffering from hemophilia. So non disjuntion will occur in father's meiosis.

In this syndrome The extra chromosome is retained because of a nondisjunction event during paternal meiosis I, maternal meiosis I, or maternal meiosis II (gametogenesis). The relevant nondisjunction in meiosis I occurs when homologous chromosomes, in this case the X and Y or two X sex chromosomes, fail to separate, producing a sperm with an X and a Y chromosome or an egg with two X chromosomes. Fertilizing a normal (X) egg with this sperm produces an XXY offspring (Klinefelter). Fertilizing a double X egg with a normal sperm also produces an XXY offspring (Klinefelter).

So from all this we can conclude that the reason behind the son's disorder and hemophilia is Nondisjunction in meiosis I of father.

So option e is correct.

gladiator answered 1 year ago

A son is born with Kleinfelter's syndrome and hemophilia. His father is normal but his mother...

A son is born with Kleinfelter's syndrome and hemophilia. His father is normal but his mother is a carrier of the recessive X-linked, blood-clotting disorder. Which of the following best describes how the boy inherited hemophillia?

a.a mother and father produce a son with hemophilia even though neither have the disease themselves....

a.a mother and father produce a son with hemophilia even though neither have the disease themselves. If this son has children with a woman who is carrier of the disease, what is the chance of having a son who has the disease and what is the chance of having a daughter with the disease? Briefly explain your answer. b. a father with a sister who has Tay Sachs has a son and daughter with a woman who also has a...

A child is born with hemophilia (inherited as an X-linked recessive) and Klinefelter's syndrome to parents...

A child is born with hemophilia (inherited as an X-linked recessive) and Klinefelter's syndrome to parents who both have normal blood clotting. In which parent (mother or father) and during which round of meiosis (I or II) did the nondisjunction event occur? * note that Klinefelter syndrome is 47 chromosomes, so 2n+1 (47,XXY)

mother wants to ensure the education of his son. On the 7th birthday of the son,...

mother wants to ensure the education of his son. On the 7th birthday of the son, he invest in a fund the amount of P 20000000 earning at 6.5% interest rate compounded monthly; on the 10th birthday another P 20000000 at an interest rate of 7.3% compounded monthly: on the 15th birthday another sum of money at 8% compounded monthly. If on the 18th birthday the son have a total withdrawable amount of P1.3M, how much is the 3rd investment?...

If a phenotypically normal woman whose father suffered from hemophilia marries a normal man, what is...

If a phenotypically normal woman whose father suffered from hemophilia marries a normal man, what is the probability of hemophilia occurring in the children produced by this marriage? (Show the cross and give the genetic ratios by sex.) In the next case, assume that the same woman had a husband with a genotypically homozygous normal mother but whose father also had hemophilia. What will then be the chance of hemophilia in the children? Give genotypic and phenotypic ratios for the...

A boy with Klinefelter syndrome (47 chromosomes, XXY) is born to a mother who is phenotypically...

A boy with Klinefelter syndrome (47 chromosomes, XXY) is born to a mother who is phenotypically normal and a father who has the X-linked skin condition called anhidrotic ectodermal dysplasia (AED). The mother's skin is completely normal with no signs of the skin abnormality. By contrast, her son has patches of normal skin and patches of abnormal skin. a) What are the genotypes of the mother and the father? (b) What is the genotype of the son? (c) Which parent...

2. Two normal parents have a son that is a carrier for hemophilia (an X-linked recessive...

2. Two normal parents have a son that is a carrier for hemophilia (an X-linked recessive disorder) and has Kleinfelter Syndrome. a. Write out the cross as described above illustrating the genotypes and phenotypes of the parents and child. b. Did the non-disjunction event occur in 1) mother, 2) father, or 3) could have occurred in either of the two parents? c. Did the nondisjunction event occur in 1) Meiosis I, 2) Meiosis II, or 3) could have occurred in...

A father racing his son has 1/ 4 the kinetic energy of the son, who has...

A father racing his son has 1/ 4 the kinetic energy of the son, who has 1/ 3 the mass of the father. The father speeds up by 1.4 m/s and then has the same kinetic energy as the son. What are the original speeds of (a) the father and (b) the son?

Hemophilia is a sex-linked trait. A hemophilic man, whose father was normal, marries a woman whose...

Hemophilia is a sex-linked trait. A hemophilic man, whose father was normal, marries a woman whose father had hemophilia and whose mother was heterozygous for hemophilia. What are the chances that their son will have hemophilia? A daughter will have hemophilia? (Since there are two possibilities for the mother, you must use the data from two Punnett Squares to answer these questions.) Mr. X has been accused by Miss Z of fathering her child. The child's blood type is AB...

A father racing his son has half the kinetic energy of the son, who has two-fifths...

A father racing his son has half the kinetic energy of the son, who has two-fifths the mass of the father. The father speeds up by 3.0 m/s and then has the same kinetic energy as the son. (a) What is the original speed of the father? m/s (b) What is the original speed of the son? m/s

Question