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In: Biology

9. List therapeutic options for COVID-19 currently under investigation.

9. List therapeutic options for COVID-19 currently under investigation.

Solutions

Expert Solution

Targets for COVID-19 treatment.

1. Spike Protein

2. Corona virus main proteinase (3CLpro).

3. Papain like protease (PLpro)

4. RNA dependent RNA polymerase (RdRp).

5. Transmembrane serine protease-2 (TMPRSS2)

.Therapeutic options for Covid-19 under investigation

Antiviral agents

Drug targets

Status

Remdesivir

Inhibits RNA-dependent RNA polymerase (RdRp)

Undergoing phase 3 clinical trial

Lopinavir

Inhibits corona virus main protease (3CLpro)

Undergoing phase 3 clinical trial

Ritonavir

Inhibits corona virus main protease (3CLpro)

Undergoing phase 3 clinical trial

Combination of Darunavir and Cobicistat

Inhibits corona virus main protease (3CLpro)

Undergoing phase 3 clinical trial

Nafomostat mesylate

Transmembrane serine protease-2 (TMPRSS2)

Phase-3 clinical trial

Camostat mesylate

Inhibits Transmembrane serine protease-2 (TMPRSS2)

Phase-2 clinical trial

6-mercaptopurine

Inhibits Papain like protease (PLpro)

Preclinical phase

           

gladiator answered 2 years ago
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