Question
In: Biology
9. List therapeutic options for COVID-19 currently under investigation.
9. List therapeutic options for COVID-19 currently under investigation.
Solutions
Expert Solution
Targets for COVID-19 treatment.
1. Spike Protein
2. Corona virus main proteinase (3CLpro).
3. Papain like protease (PLpro)
4. RNA dependent RNA polymerase (RdRp).
5. Transmembrane serine protease-2 (TMPRSS2)
.Therapeutic options for Covid-19 under investigation
|
Antiviral agents |
Drug targets |
Status |
|
Remdesivir |
Inhibits RNA-dependent RNA polymerase (RdRp) |
Undergoing phase 3 clinical trial |
|
Lopinavir |
Inhibits corona virus main protease (3CLpro) |
Undergoing phase 3 clinical trial |
|
Ritonavir |
Inhibits corona virus main protease (3CLpro) |
Undergoing phase 3 clinical trial |
|
Combination of Darunavir and Cobicistat |
Inhibits corona virus main protease (3CLpro) |
Undergoing phase 3 clinical trial |
|
Nafomostat mesylate |
Transmembrane serine protease-2 (TMPRSS2) |
Phase-3 clinical trial |
|
Camostat mesylate |
Inhibits Transmembrane serine protease-2 (TMPRSS2) |
Phase-2 clinical trial |
|
6-mercaptopurine |
Inhibits Papain like protease (PLpro) |
Preclinical phase |
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