Question

Glycosylation increases the structural diversity of the glycome and proteome. Discuss the structural differences between proteoglycans and mucins. What is the functional significance of each glycoprotein in cartilage formation and the mucosal environment of the body, respectively?

Answer 1

Mucin are the family of high molecular weight, heavily glycosylated proteins (glycoconjugates) which are produced by epithelial tissues in most animals whereas glycoprpoteins are the compounds consist of  protein bounded mucopolysaccharides which are especially present in connective tissues. mucin are a key component in most gel like secretions and serving functions from lubrication to cell signalling to forming barriers of chemical whereas proteoglycans are the major component of animal extracellularmatrix eg. collagen.

collagen a glycoprotein is a major structural protein found in cartilage extracellular matrix (approx 85%) they palys a supportiv role. neutral glycoprotein have low viscosity and can protectand lubricate gill epithelium against physical damage or injuries while the acid glycoproteins have high viscosity may help adhesion of particles in suspension in water.

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