What are structural differences between M1 pyruvate Kinase and Haemoglobin?

Expert Solution

M1 Pyruvate kinase is one of the four isozymes of Pyruvate kinase that are tissue-specific. M1 pyruvate kinase catalyzes the conversion of phospho-enol pyruvate and ADP into pyruvate and ATP. Haemoglobin is an iron-containing metalloprotein that is involved in oxygen transfer. Structurally, M1 pyruvate kinase and Haemoglobin have the following differences:

M1 Pyruvate kinase	Haemoglobin
Total structural weight: 485.22 kDa	Total structural weight: 64.55 kDa
Tetrameric protein of identical subunits, arranged in a dimer of dimers configuration	Tetrameric protein of non-identical subunits, arranged in a dimer of αβ heterodimers
Has only 1 unique protein chain	Has 2 unique protein chains
Not a metalloprotein, does not have metal atoms, although Mg acts as co-factor	A metalloprotein: Contains 1 Fe atom in every heme group
Has 1 active site per molecule	Has 4 active sites per molecule

gladiator answered 1 year ago

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