Question

In: Chemistry

List and describe three (3) reasons why phosophorylation is a highly effective means of regulating the...

List and describe three (3) reasons why phosophorylation is a highly effective means of regulating the activity of some proteins. (5 points)

Solutions

Expert Solution

  • Phosphoryl group helps in adding two negative charges to a modified protein. Electrostatic interactions which are present in the unmodified protein can be disrupted and new electrostatic interactions can be formed thus the new such structural changes can markedly alter substrate binding and catalytic activity.
  • Phosphorylation and dephosphorylation can take place in very less time interval even less than a second or over a span of hours. The kinetics is negotiatable to meet the timing needs of a physiological process.
  • Phosphate group can form three or more hydrogen bonds. The tetrahedral geometry of the phosphoryl group makes these hydrogen bonds which are highly directional, allowing for specific interactions with hydrogen-bond donors.

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