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What is the metabolic logic regarding stimulation of pyruvate dehydrogenase kinase (PDK) activity by ATP, whereas...

What is the metabolic logic regarding stimulation of pyruvate dehydrogenase kinase (PDK) activity by ATP, whereas PDK activity is inhibited by ADP?

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Summary :-

Pyruvate dehydrogenase kinase enzyme is activated in presence of adnosine triphosphate nicotinamide , adenosine dinucleotide phosphate and acetyl Co. - A whereas the activity is reduced in ADP , NAD+ and pyruvate . There are various isoenzyme of the pyruvate dehydrogenase in humans such PDK 1, PDK 2, PDK 3, PDK 4 , Each isoenzyme responds differently to the concentration of ATP and ADP . The abnormalities are the non- functioning of the pyruvate dehydrogenase kinase leads to various disorder such as the over activity of PDK 4 leads to type II diabetes .

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