Question

in 100 words or more

1. Define and describe the actions of glucocorticoids? How does the long-term use of synthetic corticosteroids affect a person? Be sure to describe the pathway involved.

2. Can a person live without a thyroid gland? What type of compensatory mechanisms would be needed to replace the actions of this gland?

Answer 1

1. Glucocorticoids inhibit many inflammation-associated molecules such as cytokines, chemokines, arachidonic acid metabolites, and adhesion molecules.

Glucocorticoids coordinate a number of processes to boost blood glucose levels.

These include, stimulation of hepatic gluconeogenesis and enhancement of muscle breakdown, thus liberating amino acids for hepatic gluconeogenesis.

In addition, glucocorticoids reduce glucose uptake by a variety of tissues.

Synthetic Corticosteroids suppress the immune system. This can lead to an increase in the rate of infections and reduce the effectiveness of vaccines and antibiotics.

The long term use of synthetic corticosteroids may cause osteoporosis which can result in bone fractures.

2. Yes can live with medicines.

If humans entire thyroid is removed, human body can't make thyroid hormone and without replacement human will develop signs and symptoms of underactive thyroid.

As a result, a person without thyroid need to take a pill every day that contains the synthetic thyroid hormone levothyroxine (Levoxyl, Synthroid, Unithroid).

thyroid medication contains the same hormones that your body produces naturally.

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