microtubules originate from a single centrosome. Give an exampl of how a natural product (toxin from...

microtubules originate from a single centrosome. Give an exampl of how a natural product (toxin from mold,fungi,or plants) can become a tool in studying the cytoskeleton.

Expert Solution

Cytochalasin D and Latrunculin are both considered toxins that have been developed by certain fungi and sponges that both promote the depolymerization of filaments. Upon addition to live cells, Cytochalasin D and Latrunculin disassemble the actin cytoskeleton and inhibit cell movements such as locomotion.

Colchicine is obtained from the autumn crocus (Colchicum autumnale). This is obtained from plant and involve in polymerization of microtubules. Upon addition of colchicine the chromosome structure can be visualized in the cells that halt cell division in metaphase stage. Furthur movement of chromosomes to opposite poles uring anaphase cannot takes place due to depolynerization of microtubules in mitotic spindle. So cell wont enter into anaphase it halts only at metaphase.

gladiator answered 2 years ago

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