The below is for a hypothetical study demonstrating the application of the concepts for superiority and...

The below is for a hypothetical study demonstrating the application of the concepts for superiority and non-inferiority testing.

A study investigated a new agent for the treatment of arthritis. Participants were randomized to receive either the current widely used (and effective) treatment or to the new experimental treatment. After 3 weeks they recorded if, based on a clinical assessment, there were improvements in symptoms (recorded as yes/no). Because of the potential large impact of age the investigators used a multiple regression model to test for differences adjusting for age. (Technically since the outcome is binary they used what is called a logistic regression model, but the analytic approach is the same.) Investigators want to test if the new treatment is non-inferior to the current treatment. Treatment is coded as 0=usual treatment and 1=new treatment so that a positive coefficient represents greater improvement with the new treatment. The study was done on a large sample and you may use the normal distribution for testing coefficients. Prior to testing the investigators selected (+/-) 0.40 for the non-inferiority parameter (delta).

Parameter	Estimate	Standard Error
Intercept	-2.57	1.11
Treat (beta1)	0.52	0.46
Age	0.03	0.02

A. Based on the above table, what is the 95% confidence interval for the coefficient for the treatment effect (beta1)?

B. Is the p-value for testing the superiority of the new treatment greater than or less than 0.05?

C. What can you conclude from the above analyses concerning the superiority of the new treatment?

D. Using the above non-inferiority parameter, what can the investigators conclude about the non-inferiority of the new treatment? Justify your response.

Solutions

Expert Solution

NOTE:: I HOPE YOUR HAPPY WITH MY ANSWER....***PLEASE SUPPORT ME WITH YOUR RATING...

***PLEASE GIVE ME "LIKE"...ITS VERY IMPORTANT FOR ME NOW....PLEASE SUPPORT ME ....THANK YOU

orchestra answered 1 year ago

Next > < Previous

Related Solutions

hoose ONE of the concepts listed below and provide a paragraph that reflects an application of...

hoose ONE of the concepts listed below and provide a paragraph that reflects an application of the concept to something you might currently be dealing with. You can disclose as much or as little as you wish to about the situation, but please describe how you can apply one of the ethical concepts to your life. • The majority view – does that help or hinder determining what’s ethical? • Do your feelings guide what is ethical, or the right...

Discuss concepts associated with mercantilism demonstrating key policies that a country would implement if they were...

Discuss concepts associated with mercantilism demonstrating key policies that a country would implement if they were to apply such a theory. What is the liberal critique of mercantilism?

Explain the below concepts in depth. Server virtualization Application virtualization Processor and memory virtualization Network virtualization...

Explain the below concepts in depth. Server virtualization Application virtualization Processor and memory virtualization Network virtualization Data and storage virtualization

Choose any IT garget, an application or a website of your interest. Study and evaluate the interface of this chosen application or website applying the concepts you have learnt in the HCI class.

Evaluate and Redesigning Application Interfaces you think are Bad DesignsChoose any IT garget, an application or a website of your interest. Study and evaluate the interface of this chosen application or website applying the concepts you have learnt in the HCI class. Redesign the interface, detailing things or principles which were not correctly used or were completely missing. Discuss how you would reuse the design principles which were wrongly used and why you added what you think was missing.Your report...

Come up with a hypothetical scenario, illustrating the legal concepts of environmental law. There are no...

Come up with a hypothetical scenario, illustrating the legal concepts of environmental law. There are no right or wrong answers, but for your own learning purposes, try to precisely and explicitly identify specific legal concept(s) by name and provide examples to support whatever points you make. 100 words or more

Judge and Cable (2010) report the results of a study demonstrating a negative relationship between weight...

Judge and Cable (2010) report the results of a study demonstrating a negative relationship between weight and income for a group of women professionals. Following are data similar to those obtained in the study. Income figures are rounded to the nearest $1,000. BMI (X) Income (Y) 22 125 26 78 37 49 31 63 40 35 27 84 42 38 33 51 24 93 38 44 SSX SSY 452 7430 Conduct a Pearson’s r hypothesis test to determine if there...

In 1974, Loftus and Palmer conducted a classic study demonstrating how the language used to ask...

In 1974, Loftus and Palmer conducted a classic study demonstrating how the language used to ask a question can influence eyewitness memory. In the study, college students watched a film of an automobile accident and then were asked questions about what they saw. One group was asked, “About how fast were the cars going when they smashed into each other?” Another group was asked the same question except the verb was changed to “hit” instead of “smashed into.” The “smashed...

Create a Java application that will exhibit concurrency concepts. Your application should create two threads that will act as counters.

JAVACreate a Java application that will exhibit concurrency concepts. Your application should create two threads that will act as counters. One thread should count up to 20. Once thread one reaches 20, then a second thread should be used to count down to 0.

Create a C++ application that will exhibit concurrency concepts. Your application should create two threads that will act as counters.

C++Create a C++ application that will exhibit concurrency concepts. Your application should create two threads that will act as counters. One thread should count up to 20. Once thread one reaches 20, then a second thread should be used to count down to 0.

Create a C++ application that will exhibit concurrency concepts. Your application should create two threads that will act as counters.

C++ application:Create a C++ application that will exhibit concurrency concepts. Your application should create two threads that will act as counters. One thread should count up to 20. Once thread one reaches 20, then a second thread should be used to count down to 0.For your created code, provide a written analysis of appropriate concepts that could impact your application.Please Specifically, Address: Performance Issues with Concurrency Vulnerabilities Exhibited with use of Strings and Security of the Data Types used.

Subjects