Aspartate transcarbamoylase (ATCase) catalyzes the first step in the biosynthesis of a nucleotide. The end product...

Aspartate transcarbamoylase (ATCase) catalyzes the first step in the biosynthesis of a nucleotide. The end product of the pathway, cytidine 5’-triphosphate (CTP), in turn inhibits ATCase activity. This effect can be overcome by the addition of ATP.

a) Sketch the enzyme activity curve of ATCase alone, ATCase + CTP, & ATCase + ATP. Explain your rationale.

b) The regulation of ATCase activity by CTP exemplifies what TWO types of regulation?

Expert Solution

queen_honey_blossom answered 1 year ago

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