Based on what you know about metabolism from the lectures you have had so far in...

Based on what you know about metabolism from the lectures you have had so far in this course, which two of the following would you expect to be the MOST LIKELY to have signs and symptoms that are nearly identical to each other?

		TPID (triose phosphate isomerase deficiency, an inability to make triose phosphate isomerase)
		Arsenate poisoning (arsenate can substitute for phosphate, but bonds between AsO₄^3- and carbohydrates instantly hydrolyze whereas acyl phosphate bonds do not)
		Beriberi, a dietary deficiency of thiamine
		A dietary deficiency of biotin
		Arsenite poisoning (arsenite inactivates lipoamide)

Expert Solution

arsenate poisoning and beriberi ( thiamine deficiency) shows similar signs and symptoms

Arsenic interferes with cellular longevity by allosteric inhibition of an essential metabolic enzyme pyruvate dehydrogenase (PDH) complex, which catalyzes the oxidation of pyruvate to acetyl-CoA by NAD+. With the enzyme inhibited, the energy system of the cell is disrupted resulting in cellular apoptosis. Biochemically, arsenic prevents use of thiamine resulting in a clinical picture resembling thiamine deficiency

signs and symptoms : vomiting, abdominal pain , encephalopathy,watery diarrhoea that contains blood .

gladiator answered 3 years ago

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