In: Biology
Transcription of the mammalian Cytochrome P450 1A1 gene is induced by xenobiotics such as dioxin. The mechanism of induction illustrates many steps which are typical of signal-regulated transcription factors. (16 marks)
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Answer:
Here are the following steps involved in the Cytochrome P450 1A1 gene induction by dioxin:
Make groups of the cells with and without induction by dioxin. This chemical is an inhibitor of Cyp1a1 and Cyp1b1.
The mRNAs of Cyp1a1, Cyp1b1, and ribosomal subunit 36b4 is produced by a quantitative real-time polymerase chain reaction.
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