Describe how members of the CREB, CREB-like and AP1 families of transcription factors regulate gene transcription...

Describe how members of the CREB, CREB-like and AP1 families of transcription factors regulate gene transcription

Outline in detail how activation of PKA, MAPKs and CaMKII can lead to gene transcription through CREB

Expert Solution

CREB stands for cAMP response element binding protein. It is a cellular transcription factor. It binds to ceratin DNA sequences called cAMP response elements, thereby increasing or decreasing the transcription of genes. CRE elements are found in the promoter or enhancer regions of genes. CREB protein is activated by the protein kinase by virtue of a second messenger. Now, CREB binds to CRE which is itself CBP which allows it to co activates the genes, allowing it to switch ceratin genes on or off.

BzpF is a CREB like transcription factor which integrates PKA signalling which regulate transcription and helps in production of spores.

AP1 transcription factors stands for Activator Protein 1. It plays a central role in the expression of neural gene expression by extracellular signals. AP1 regulates the gene transcription via Protein Kinase pathway. They bind DNA as heterodimers. Stimulation of AP1 produces two different effects. The cell makes more and more Fos and Jun through increased expression of the genes. AP1 is a transcription factor which is closely related to cell proliferation. AP1 mediates through increased expression of IL2

gladiator answered 1 year ago

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