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1-Six months after starting atorvastatin therapy, a person’s total and LDL cholesterol levels stayed higher than...

1-Six months after starting atorvastatin therapy, a person’s total and LDL cholesterol levels stayed higher than normal, and he continued to have anginal episodes in spite of good adherence to his angina drugs. His doctor will add ezetimibe. Which of the drugs is the most precise explanation of ezetimibe’s mechanism of an action?

Reduced lipid synthesis in adipose tissue

Amplified lipid hydrolysis by lipoprotein lipase

Decreased gastrointestinal absorption of cholesterol

Reduced secretion of VLDL by the liver

Amplified endocytosis of HDL by the liver

2-A 53-year-old man has a history of frequent cases of pain due to calcium-based renal stones. A careful examination shows that he has a problem in proximal tubular calcium reabsorption that leads to high levels of calcium salts in the urine. The most beneficial diuretic drug in the management of calcium stones is

Chlorthalidone

Ethacrynic acid

Diazoxide

Spironolactone

Mannitol

3-A patient will undergo a major orthopedic surgery two hours from now. He will not be able to walk for 2 months so he will need drug or drugs to prevent deep vein thrombosis. Which of the following should be started for this indication?

Heparin on the first day and warfarin on the seventh day

None of the listed

Warfarin and heparin on the seventh day

Warfarin on the first day and heparin on the seventh day

Solutions

Expert Solution

1) ezetimibe’s mechanism of an action --

It works by decreased gastrointestinal absorption of cholesterol..
[ In this above mechanism Ezetimibe reduce the cholesterol level in the blood..]

2) The most beneficial diuretic drug in the management of calcium stones is--

Chlorthalidone..

[ Chlorthalidone belongs to the group of Thiazide diuretics.. Thiazide diuretics helps to decrease the amount of calcium in the tubules & helps to return these calcium substance to the blood serum..Thus it has an effect in the management of Calcium stones.. ]


3) The following drug should be started for prevent Deep vein Thrombosis--

Heparin on the first day and warfarin on the seventh day..

[ Heparin therapy should be started at initial level and then continued with any other Anticoagulant drug..( for ex- Warfarin )... ]

Nightingale answered 2 years ago
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