Question

Why the hydrophobic effect is a powerful organizing principle in biochemistry

Answer 1

Biochemical organisation based on the synthesis and assembly of macromalecules such as protein, lipids and carbohydrate in the cell memebrane and intracellular cell compartments by the unique hydrophobic forces and these hydrophobic organisation are under the control of thermodynamic.Protein folding is driven by the hydrophobic interaction and it have a tendency to isolate hydrophobic molecules from water. During protein folding and protein assembly in cell membrane, hydrophobic chain of protein buried in the interior of the protein. These hydrophobic chains of proteins are important to form the membrane channel to transport polar molecules. Hydrophobic effects makes the cell membrane selectively permeable. Lipids are amphiphilic in nature and have both hydrophilic and hydrophobic region and during the formation of micelles, liposomes and vesicles its tends to aggregate into large structure in water and trap hydrophilic compounds inside the vesicles and used as a carrier and trasnpoters.Hydrophobic effects increases the affinity binding during chromatography and also in enzyme- substrate interaction.