Question

What would happen if you implanted a capsule that slowly released high levels of estradiol in the AVPV of a female rat?

Answer 1

Answer :

1.As we all know that AVPV (Anteroventral periventricular nucleus) female rodents give positive feedback responses that triggers ovulation.

2.That is female undergo hormonal changes both naturally during their lives and as a result of sex hormone treatments.

3.Objective of this experiment is effect of hormones over sleep and responses to sleep loss.

4.If female rats ovariectomized and implanted subcutaneously Estradiol.

5.As previous study shows, after 2 weeks, sleep/wake states, recorded during a 24-h baseline period.

6.At baseline and particularly in the dark phase, ovariectomized rats treated with estradiol or estradiol plus progesterone, female rat spent more time awake at the expense of Non-rapid eye movement sleep (NREMS) and/or REMS.

7.While those given progesterone alone spent less time in REMS than ovariectomized rats receiving no hormones.

8.Following sleep deprivation, all rats showed rebound increases in NREMS and REMS, but the relative increase in REMS was larger in females receiving hormones, especially high estradiol.

9.Estradiol promotes arousal in the active phase in sleep-satiated rats, but after sleep loss, both estradiol and progesterone selectively facilitate REMS rebound while reducing NREMS intensity.

10.These results indicate that effects of ovarian hormones on recovery sleep differ from those on spontaneous sleep and may affect recovery of sleep related functions after sleep loss.

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