Question

In: Biology

Digitalis affects what protein? A) potassium ion channels b)ligand gated channels c)sodium/potassium ATPase d)calcium ATPase e)sodium...

Digitalis affects what protein?

A) potassium ion channels

b)ligand gated channels

c)sodium/potassium ATPase

d)calcium ATPase

e)sodium ion channels

Solutions

Expert Solution

Digitalis :-
• These are drugs of group cardiac glycosides.
• These drugs increase heart contractility, so these are used in heart failure.

Mechanism of action :-
• This drug acts on sodium- potassium ATPase pump of heart myocytes.
• Now this pump is unable to pump sodium ions outside the cell and sodium ion concentration is increased in cell.
• This increased sodium ion concentration increases the activity of sodium- calcium exchanger or calcium ATPase and it results into increased calcium ion concentration in cell.
• Increased calcium increases contraction of muscle fibres and it ultimately results into increased contractility of heart..

Now in question,
Option (c) is correct answer.
Sodium/ potassium ATPase pump.

Other options -
• Potassium ion channels are blocked by drugs like amiodarone, dronedarone and bretylium.
• Ligand gated ion channels are transmembrane protein complexes and their activities are controlled by neurotransmitters.
For example - Ion channels with nicotinic receptors are activated by acetylcholine.
• Calcium ATPase activity is controlled by activity of sodium potassium ATPase. ( *Explained above).
• Sodium ion channel blocker durgs are - Quinidine, procainamide. These drugs are used as antiarrhythmic drugs.


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