Indicate whether the following statements apply to exotoxins or endotoxins 1. the effect is tissue specific...

Indicate whether the following statements apply to exotoxins or endotoxins 1. the effect is tissue specific e.g neurotoxin 2. these are made of protein and are often secreted by the pathogen 3. these are only produced by gram negative organisms 4. we are vaccinated against some of these 5. this causes diseases by producing a massive, systemic inflammatory response 6. this one tends to be more heat stable 7. this disease causing component is lipid A

Expert Solution

1. the effect is tissue specific e.g neurotoxin: Exotoxin

2. these are made of protein and are often secreted by the pathogen: Exotoxins

3. these are only produced by gram negative organisms: Endotoxins

4. we are vaccinated against some of these: Exotoxins

5. this causes diseases by producing a massive, systemic inflammatory response: Exotoxins ( Only Super antigens) triggers inflammatory response

It should also be remembered that Endotoxins lipid A also triggers inflammatory response

6. this one tends to be more heat stable : Endotoxins

7. this disease causing component is lipid A: Endotoxins

Explanation: Exotoxins are proteins secreted from bacteria with tissue specific damaging effectsThese are destroyed by heating as most of them are thermolabile They can act both locally and systmatically They are responsible for generation of antibodies in the immune system and hence vaccines and toxoids are developed against exotoxins producing bacteria

Endotoxins consists of lipid A of lipopoysaccharides of cell wall of gram negative bacterium trigger inflammatory response which helps in clearing the infection When systematic widespread of endotoxins is present it leads to septic shock or endotoxic shock lipid A is released after the cell lysis These are heat stable

gladiator answered 1 year ago

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