Question

Approximately 25% of human tumors are found to have activating mutations in Ras. How do these mutations contribute to the tumor development?

Answer 1

Oncogenes are genes that are firmly connected to cancer, and the gene that encodes Ras was among the first to be found. Transformation of an oncogene changes the capacity of the encoded protein, making the harmful properties that are required for growth to develop and spread cancer. For example, a few oncogenes encode proteins engaged with programmed cell death, for example, p53 tumor silencer, and the oncogenic transformation enables the malignancy cell to dodge our capable defense against strange development. Ras is engaged with the signs go between cells that control the measure of development that is permitted whenever. Cancer causing change of Ras makes a type of the protein that is dependably on. This is a calamity, in light of the fact that the changed Ras ceaselessly tells the malignancy cells that it is alright to increase, without the ordinary furthest reaches that control cell development.