Explain the mechanism by which a missense mutation in the RAS gene that impairs the GTPase...

Explain the mechanism by which a missense mutation in the RAS gene that impairs the GTPase activity of the RAS protein promotes cancer cell division.

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gladiator answered 1 year ago

If the GTPase function of Ras is destroyed, Ras will always be on/activated. This causes increased...

If the GTPase function of Ras is destroyed, Ras will always be on/activated. This causes increased Cyclin D and S phase genes expression by transcription factor E2F. Describe how this activation of Ras causes this increased expression of both Cyclin D and S phase genes by explaining the role/function of the following: Raf, MEK, ERK Myc Cyclin D/Cdk4 or Cdk 6 Rb E2F also indicate if any of the above are a kinase or transcription factor

What is meant by a missense mutation? What is a nonsense mutation?

What is meant by a missense mutation?What is a nonsense mutation?What is a silent mutation?What is a frameshift mutation? Give an example of each type of mutation and discuss the effect on a protein product.

What is the difference between a silent mutation, point mutation and a missense mutation?

Understand the role of each in cell signaling: GTPase RAS and MAP kinase

Describe each of the below mutations AND provide an example of each. Point mutation Missense mutation...

Describe each of the below mutations AND provide an example of each. Point mutation Missense mutation Nonsense mutation Silent mutation Transition Transversion Frameshift mutation

How Gene Mutation Mechanism affect the six different types of rare bone disease?

under what condition GTPase-activating protein (GAP) Switches off the RAS-MAPK signaling pathway during EGFR-mediated Ras-activation?

22. You are studying a toxin that prevents RAS, a GTPase from hydrolyzing GTP. You find...

22. You are studying a toxin that prevents RAS, a GTPase from hydrolyzing GTP. You find that this toxin increase the amount of cell growth. Please explain this finding. 23. You find that some cells have mutations that permanently deactivate Raf in this pathway. Please state whether you agree or the Ras-affecting drug from the previous question will increase the amount of cell growth in the inactive Raf mutants. Agree or Disagree?

Explain the location and mechanism of the resistant mutation, and why it allows the mosquito to...

Explain the location and mechanism of the resistant mutation, and why it allows the mosquito to be resistant to pestisides.

Ras nucleotide exchange is stimulated by ___. A mutation in RTK receptor that allows the receptor...

Ras nucleotide exchange is stimulated by ___. A mutation in RTK receptor that allows the receptor to bind the ligand and pair with a wild-type receptor but blocks signal transduction is classified as a ________ ________ mutation, whereas a mutation that activates RTK pairing signal transduction even in the absence of ligand is classified as a ______________ _______ mutation. PTEN is a phosphatase that removes a phosphate group from ____, thereby preventing its activation of Akt kinase.

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