_____________ _ produces the second messengers IP3 and diacylglycerol (DAG). In heterotrimeric G-proteins, the ____ subunit...

_____________ _ produces the second messengers IP3 and diacylglycerol (DAG).
In heterotrimeric G-proteins, the ____ subunit stimulates adenylyl cyclase.
Types of regulators of G-protein signaling (RGS) proteins known as ____ accelerate termination of signaling by stimulating a G-protein to __________ GTP.

Expert Solution

when a ligand binds to GPCR, the conformation of the GPCR changes then trimeric G proteins associate with GDP on the G-alpha is replaced with GTP, then G alpha dissociates from G beta-gamma subunits, Galpha-s stimulates adenylate cyclase and G beta-gamma activates phospholipase C, which cleaves Phosphatidylinositol 4,5-bisphosphate to IP3 and diacylglycerol.

G alpha is deactivated when GTPase activating protein hydrolyze GTP to GDP.

Phospholipase C produces the second messengers IP3 and diacylglycerol (DAG).
In heterotrimeric G-proteins, the G alphas subunit stimulates adenylyl cyclase.
Types of regulators of G-protein signaling (RGS) proteins known as GTPase activating protein (GAP ) accelerate termination of signaling by stimulating a G-protein to hydrolyze GTP.

gladiator answered 2 years ago

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