Which of the following statements regarding diacylglycerol (DAG) and inositol triphosphate (IP3) is not true? A....

Which of the following statements regarding diacylglycerol (DAG) and inositol triphosphate (IP3) is not true?

A. They only bind to very specfic cell surface receptors

B. Both are important second messanger molecules

C. They are lipids

D. They are produced by the metabolism of plasma membrane components

Expert Solution

Ans (A) : They only bind to very specific cell surface receptors (This statement is not true about DAG & IP3) ----DAG & IP3 do not bind to any cell surface receptors , instead they performs the following functions:

- IP3 which diffuses through the cytosol & releases calcium ions from the ER by binding to receptors that are ligang gated calcium ion channels on ER not plasma membrane.

- DAG which remains in the membrane & with phosphatidyl -serine, calcium ion, helps to activates the enzyme protein kinase C, which is recruited ftom cytosol to cytosolic face of plasma membrane .

* The statements true about DAG & IP3 are :

B) Both are important secondary messenger molecules : DAG & IP3 both act as secondary messengers (targets the other molecules) formed from the cleavage of phosphatidylinositol 4,5 - phosphate (PIP2) by phospholipase C .One secondary messenger DAG remains associated with the plasma membrane, the other secondary messenger IP3 is released into the cytosol , where it acts to signal release of calcium ions from ER.

C) They are lipids : DAG is a lipid, so it remains associated with plasma membrane. IP3 is a small polar molecule that is released into the cytosol.

D) They are produced by the metabolism of plama membrane components : DAG & IP3 are produced by the cleavage of PIP2 , which is a membrane phospholipid (a component of plasma membrane ), loaclized to the inner leaflet of phospholipid bilayer.

Hope this will help you☺

gladiator answered 6 months ago

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