In: Biology
Ans (A) : They only bind to very specific cell surface receptors (This statement is not true about DAG & IP3) ----DAG & IP3 do not bind to any cell surface receptors , instead they performs the following functions:
- IP3 which diffuses through the cytosol & releases calcium ions from the ER by binding to receptors that are ligang gated calcium ion channels on ER not plasma membrane.
- DAG which remains in the membrane & with phosphatidyl -serine, calcium ion, helps to activates the enzyme protein kinase C, which is recruited ftom cytosol to cytosolic face of plasma membrane .
* The statements true about DAG & IP3 are :
B) Both are important secondary messenger molecules : DAG & IP3 both act as secondary messengers (targets the other molecules) formed from the cleavage of phosphatidylinositol 4,5 - phosphate (PIP2) by phospholipase C .One secondary messenger DAG remains associated with the plasma membrane, the other secondary messenger IP3 is released into the cytosol , where it acts to signal release of calcium ions from ER.
C) They are lipids : DAG is a lipid, so it remains associated with plasma membrane. IP3 is a small polar molecule that is released into the cytosol.
D) They are produced by the metabolism of plama membrane components : DAG & IP3 are produced by the cleavage of PIP2 , which is a membrane phospholipid (a component of plasma membrane ), loaclized to the inner leaflet of phospholipid bilayer.
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