The results of the subject's blood tests showed elevated levels of lactate, pyruvate, and lactate dehydrogenase....

The results of the subject's blood tests showed elevated levels of lactate, pyruvate, and lactate dehydrogenase. Describe the most likely explanation of these test results by completing the passage.

Decreased activity of one or more subunits of ____ (the alpha-ketoglutarate dehydrogenase complex, the PDH complex, lactate dehydrogenase) directly causes ____ (pyruvate, lactate, CO2) to accumulate. The accumulation of this metabolite leads to increased production of ____ (the alpha-ketoglutarate dehydrogenase complex, the PDH complex, lactate dehydrogenase) which then converts ____ (pyruvate to lactate, lactate to pyruvate, pyruvate to acetyl CoA, alpha-ketoglutarate to succinyl CoA).

Expert Solution

Decreased activity of one or more subunits of PDH complex (the alpha-ketoglutarate dehydrogenase complex, the PDH complex, lactate dehydrogenase) directly causes Pyruvate (pyruvate, lactate, CO2) to accumulate. The accumulation of this metabolite leads to increased production of lactate dehydrogenase_ (the alpha-ketoglutarate dehydrogenase complex, the PDH complex, lactate dehydrogenase) which then converts pyruvate to lactate (pyruvate to lactate, lactate to pyruvate, pyruvate to acetyl CoA, alpha-ketoglutarate to succinyl CoA).

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gladiator answered 2 years ago

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