a.) Review the structure and function of a GPCR. b.) Define signal transduction—include in the definition...

a.) Review the structure and function of a GPCR.

b.) Define signal transduction—include in the definition a listing of all components necessary to carry out this process

c.) Describe the function(s) of signal transduction. Be specific.

d.) Describe the process of desensitization a GPCR goes through.

e.) Some techniques involved in these types of analyses might be protein separation, gel electrophoresis, Western blotting, calcium assays and PCR. Choose one of the five mentioned techniques and detail the theory behind it and how the technique is performed.

Expert Solution

a. GPCR or G protein coupled receptors is a membrane protein which mediate our sense of vision, smell , taste and pain. It helps to regulate many bodily functions. It possess seven membrane spanning domains or transmembrane helices. It also contains two cysteine structures which form disulfide bonds to stabilize the structure of GPCR.

B. Signal transduction is a process by which a chemical or physical signal or any stimulation is transferred across the cell membrane from exterior to interior, it includes the signal to bind to the receptors or ligands of the cell which brings receptor activation and induce a response through series of molecular events.

C. Signal transduction helps to regulate process of cell like metabolism , growth , differentiation and to provide an appropriate response.

D. Desensitization of GPCR means the loss in the response or decreased responsiveness with the prolonged exposure to agonist.

gladiator answered 1 year ago

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