What is the number of ATP and ATP equivalents that can be produced via oxidative phosphorylation...

What is the number of ATP and ATP equivalents that can be produced via oxidative phosphorylation per cycle of the Citric Acid Cycle (CAC), starting from pyruvate? B) What is the number of ATP and ATP equivalents that can potentially be produced if Complex I of the Electron Transport System (ETS) is inhibited? C) If Complex II of the ETS is inhibited? D) If Complex III of the ETS is inhibited? E) If Complex IV of the ETS is inhibited?

Expert Solution

What is the number of ATP and ATP equivalents that can be produced via oxidative phosphorylation per cycle of the Citric Acid Cycle (CAC), starting from pyruvate?

link reaction produces 1 NADH2

and in citric acid cycle 3 NADH2 + 1 FADH2 + 1 ATP

so total ATP produced = 1

ATP equivalents are NADH2 = 4 and FADH2= 1

B) What is the number of ATP and ATP equivalents that can potentially be produced if Complex I of the Electron Transport System (ETS) is inhibited?

None of the NADH2 will produce ATP, due to inhibition of complex I.

but FADH2 will go through this complex producing 1.5 ATP in Glycolate-glyoxylate shuttle.

So Total ATP from citric acid cycle = 1+1.5 = 2.5 ATP equivalent

C) If Complex II of the ETS is inhibited?

the NADH2 will produce 2.5 ATP per molecule.

so 4 NADH2 will produce 10 ATP

D) If Complex III of the ETS is inhibited

If Complex III of the ETS is inhibited?

Only 1 ATP will be produced

E) If Complex IV of the ETS is inhibited?

only 1 ATP produced from the citric acid cycle, the organism will die due to the absence of terminal electron acceptor.

gladiator answered 1 year ago

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