Question

Which of the following is a selective inhibitor of monoamine oxidase B (MAO-B) and, therefore, useful in treating parkinsonism?

A.Carbidopa

B.Bromocnptine

C.Selegiline

D.Tranylcypromine

E.Phenelzine

A male patient is brought to the emergency department following ingestion of an unknown substance. He is found to have an elevated temperature, hot and flushed skin, dilated pupils, and tachycardia. Of the following, which would most likely cause these findings?

a.Succinylcholine

b.Pilocarpine

c.Organophosphates

d.Tubocararine

Atropine

Answer 1

1. Answer is C selegiline. Selegiline is a irreversible selective inhibitor of monoamine oxidase B. Used to treat parkinsonism.

Carbidopa is a dopaminergic agent used to treat parkinson disease so it is not the answer.

Bromocriptine is a dopaminergic agent used to treat parkinson disease, hyperprolactinaemia, pituitary tumor. So it is not the answer.

Tranylcypromine is a irreversible non-selective monoamine oxidase inhibitor used to treat major depression, dysthymic disorder, atypical depression. So it is not the answer.

Phenelzine is a non-selective and irreversible monoamine oxidase inhibitor used as a antidepressants and anxiolytic. So it is not the answer.

2. Answer is E atropine. Atropine is a anticholinergic drug. Atropine poisoning will cause increase temperature, hot and flushed skin, dilated pupil, tachycardia.

Succinylcholine is a muscle relaxant used during surgery and cause low blood pressure, respiratory depression. So it is not the answer.

Pilocarpine is a cholinergic agent used to treat glaucoma cause constriction of pupil toxicity will cause hypotension, tremor, bradycardia, seizure. So it is not the answer.

Organophosphate will cause increase salivation, sweating, miosis, diarrhea, vomiting, confusion so it is not the answer.

Tubocurarine used as a skeletal muscle relaxant during surgery will cause hypotension, increase salivation, bronchospasm, respiratory depression. So it is not the answer.