Question

In: Nursing

How would the following conditions, or patient populations, affect drug dosing: Renal dyfunction Hepatic dysfunction Obesity...

  • How would the following conditions, or patient populations, affect drug dosing:
    • Renal dyfunction
    • Hepatic dysfunction
    • Obesity
    • Pediatrics
    • Geriatrics

Solutions

Expert Solution

RENAL DYSFUNCTION; The Drug dose is based on the body system functioning especially kidney and liver functions , Renal dysfunction may affect the drug elimination so the dosage should be managed. That is , drug dosing faces various challenges include residual drug clearence, and fluid accumulation. Renak dysfunction affects the drug excretion and it may accumulate in body so maintain drug dose in patient with kidney disease, and must decrease drug dose.

HEPATIC DYSFUNCTION; Patient with hepatic dysfunction can affect the drug dosing , increasing drug dose may affect the liver functions , Liver is the site of drug detoxification and metabolism so increased drug dose in liver dysfunction can result in accumulation of toxic levels in body.

OBESITY; Body size is the important factor when calculating drug dose, drug achieves a higher concentration in smaller people given the same dosage, drug dose calculate with the body weight if patient have more weight the drug dose may increase, if patient have less weight the dosing is decreased.

PEDIATRICS; In pediatrics the liver metabolizing enzymes are increased, metabolism usually faster than adults.so when taking drug to child is with small doses , small doses can result more effect.

GERIATRICS; Elderly patients are more sensitive to drugs and exhibit more variability in response, in older adults have decreased hepatic functions will affect metabolism, and in excretion elderly have decreased renal function so managing drug dose is important in geriatrics.


Related Solutions

describe how Phase 1 and phase 2 metabolism influences/affects renal and hepatic elimination of a drug
describe how Phase 1 and phase 2 metabolism influences/affects renal and hepatic elimination of a drug
describe how phase I and phase II metabolism influence/affect i) renal and ii) hepatic elimination of...
describe how phase I and phase II metabolism influence/affect i) renal and ii) hepatic elimination of a drug? Answers must be detailed and complete sentences.
Which of the following is found in the thoracic cavity? Hepatic Portal Vein Renal arteries Superior...
Which of the following is found in the thoracic cavity? Hepatic Portal Vein Renal arteries Superior Mesenteric vein Celiac Trunk Azygos vein The Radial and Ulnar veins join to create the..... Brachial vein Cephalic vein Basilic vein Axillary artery None of these Cardiac veins direct blood into the..... Coronary sinus Right coronary artery Left Atrium Aorta Papillary muscles
Your patient has the following conditions and takes the following meds. (10 points) Obesity (BMI 56)...
Your patient has the following conditions and takes the following meds. (10 points) Obesity (BMI 56) (takes Saxenda) HTN (takes atenolol) Hyperlipidemia (takes Zocor) (a) Based on these meds, tell me how you would monitor exercise intensity and why? (b) Based on the conditions, tell me what considerations you would need for programming. HINT: think contraindications AND awareness/ sensitivity to the obese client. *Please explain in most detail possible*
how would a drug that is soluble in the blood affect hemoglobin? biochem
how would a drug that is soluble in the blood affect hemoglobin? biochem
A patient presenting with which symptom of a renal calculi would likely warrant the patient needing...
A patient presenting with which symptom of a renal calculi would likely warrant the patient needing surgical or procedural interventions to eradicate the stone , rather than the patient being able to pass the stone independently
Which is the most common valvular dysfunction and how does it affect blood flow?
Which is the most common valvular dysfunction and how does it affect blood flow?
How does the respiratory system affect the renal, endocrine, and circulatory system?
How does the respiratory system affect the renal, endocrine, and circulatory system?
A. How can you manage nutritionally a patient suffered renal failure? The patient is male, hypertensive,...
A. How can you manage nutritionally a patient suffered renal failure? The patient is male, hypertensive, diabetic type-2, obese, and aged 58 years. The patient has been advised to postpone the renal dialysis (Weight is 110 kg, height is 180 cm). 1. What are the requirements of macronutrients? 2. What are the requirements of water? What about hot weather? 3. What are the required micronutrients? 4. If anemia and osteoporosis how can you manage the complications? 5. If patient has...
What electrolytes would you expect to be low in a patient with renal disease? What electrolytes...
What electrolytes would you expect to be low in a patient with renal disease? What electrolytes would you expect to be high?
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT