Question

11. The cannabinoid receptor is highly expressed in the CNS is

a. CB1

b. CB2

c. CB3

d. None of the above

3. Clathrin is assembled into

a. hexamers

b. triskelions

c. pentamers

d. None of the above

4. Prozac targets this membrane protein

a. Dopamine transporter

b. Estrogen receptor

c. Connexons

d. None of the above

Answer 1

1. Cannabinoid receptor is a G protein-coupled cell membrane receptor located throughout the body in various tissue. There 3 subtype of cannabinoid receptors CB1, CB2, and CB3. These receptors involved in sensation of pain

CB1 subtype highly present in the brain (CNS) where as CB2 is highly expressed in immune system. Position of Subtype CB3 need to be establish in future

Answer is a. CB1

2. Clathrin is a protein which has a triskelion shape, it involved in receptor mediated endocytosis by assembling into a polyhedral lattice from its triskelia subunits and form a vesicle. Clathrin triskelion primarily assembled to form hexamers which provide flat Surface for lattice and pentamers to form curved surface for lattice. These pentamers and hexamers connects together to form a single polyhydral vesicle

Answer is d. None of the above

3. Generic name of Prozac is fluoxetine, pharmacologically it is a selective serotonin reuptake inhibitors (SSRIs) used in the treatment of depression (It is an antidepressant).

Its main target is serotonin transporter (SERT) present in the serotonergic neurons. serotonin transporter (SERT) reuptake the serotonin from the synaptic cleft. Fluoxetine block its action and prevent reuptake serotonin from the synaptic cleft, there by boost the level of serotonin in site of action

Answer is d. None of the above