Question

Choose correct answers: Which of the following are true of insulin receptors?

Question 5 options:

A	found on muscle cells
B	found predominately on beta cells
C	bind insulin and change shape
D	allow insulin to enter the cell
E	Enzyme linked receptor (RTK)
F	G protein coupled receptor
G	only perform one function in response to ligand binding

Answer 1

A. Found on muscle cells -- True

Insulin receptors are present on the surface of muscle cells

B. Found predominately on beta cells -- True

Insulin receptor A (IR-A) and Insulin receptor B (IR-B) predominantly found on betacells.

C bind insulin and change shape

When insulin binds to its receptor, the binding signal triggers the change in shape that is propagated inside the cell.

D. Allow insulin to enter the cell -- False

Insulin receptors wont allow the insulin to inter into the cell

E. Enzyme linked receptor (RTK) -- True

Insulin receptors contain a single transmembrane domain with an extracellular N-terminal ligand binding domain and a cytoplasmic C-terminus with tyrosine kinase activity.

F. G protein coupled receptor -- False

G protein coupled receptors regulate glucose stimulated insulin secretion

G. only perform one function in response to ligand binding -- False

In response to ligand binding, Insulin receptors activates the glycogen synthesis by inhibiting the enzymes and slow down the PI(3)K pathway. At the same time, it will promote the function of the enzymes that provide a positive feedback for the pathway like the AKT and P70 enzymes.