Question

Oxidative phosphorylation is dependent on all of the following EXCEPT:

a. an intact mitochondrial membrane

b. the activity of ATP-ADP translocase

c. the reduction-oxidation state of iron

d. the reduction of oxygen

e. there are no exceptions. It is dependent on all A-D.

Answer 1

Q. Ans is E.

Oxidative phosphorylation occurs to form ATP from ADP during the transfer of an electron from different high energy compounds formed during the oxidation of macromolecules.

The oxidative phosphorylation process is coupled with an electron transfer chain. To perform both these pathways an intact inner membrane of mitochondria is very much required as all the important enzymes and electron carriers of ETC are present in the inner mitochondrial membrane.

The transfer of electron form high energy compound is dependent on various iron-containing heme proteins, which undergoes a simultaneous oxidation-reduction reaction to transfer the electron to its next carrier.

The terminal electron acceptor of this chain is molecular oxygen which undergoes reduction by accepting hydrogen and from water.

The whole process is coupled with ATP formation and formed ATP is transferred to the matrix of mitochondria in exchange of ADP, so that the formation of ATP remains continuous. This transfer of ATP and ADP occurs by ATP-ADP translocase. This is one of the most abundant protein of inner mitochondrial membrane.