Create a biological molecular or genetic network. using. It can be genes and proteins interacting with...

Create a biological molecular or genetic network. using. It can be genes and proteins interacting with one another, including protein-protein, protein-DNA, genetic and enzymatic interactions. Please refrain from mapping physiological or ecological networks. Any interactions among biological entities within a cell will work. I do expect the nodes (genes/proteins/molecules) and the interactions between them to be based on real evidence, and that the values that you choose for them are reasonable. In fact, you'll have to share a reference to the sources that you used to put together your network, and some narrative to explain some of your decisions in compiling the network together.

Solutions

Expert Solution

A genetic network is mapped by using NetSim which governing the fruit fly's (Drosophila melanogaster) intestinal progenitors differentiation, on he basis of research article explaining the function of a escargot (Esg) gene in governing the maintenance as well as differentiation of these progenitors. Expression of differentiation genes inhibited by Esg in these cells, protecting these cells as progenitors. Hence, an inhibitory link is set up between Esg as well as differentiation genes. Also in progenitor cells, Esg is only expressed, an inhibitory connection also drew from differentiation genes rear to Esg, to show the fact that if genes diferentiations do their work the Esg expression will be decreased.

In this network an inhibitory connection is also drew from Esg to Amun, other from Amun to Notch also a positive interaction from Notch to differentiation genes. Lastly, the authors in the article used Esg expression's RNAi-mediated knockdown to reduce the Esg's activity within progenitor cells, that is modeled by adding a node called "esgRNAi" that inhibits the "Esg" node.To motivate the normal cell's state, the initial value of "esgRNAi" is set to "0.0"; but having a initial value for this node which is greater than 0 will induce what occurs to cells if the esgRNAi is indicated experimentally to retard Esg.

The share code for this network is: YPNC.

gladiator answered 1 year ago

Next > < Previous

Related Solutions

State the molecular function of the proteins encoded by each of the following genes. Briefly state...

State the molecular function of the proteins encoded by each of the following genes. Briefly state how disruption of this gene results in the recessive phenotype. R gene in peas Y gene in peas Cystic Fibrosis

Influential genes and proteins in dairy cattle: Genetic methods have been used to examine regions of...

Influential genes and proteins in dairy cattle: Genetic methods have been used to examine regions of the dairy cattle genome that appear to have been under selection. A positive signature of selection in a given region implies the genes contained therein are potentially important for aspects of milk production such as yield. Two such genes found to be of importance in dairy cattle are DGAT1 (which encodes the fat biosynthesis enzyme diacylglycerol o-acyltransferase 1) and GHR (which encodes the growth...

5). Considering that genes can code only for RNA or proteins, how can the synthesis of...

5). Considering that genes can code only for RNA or proteins, how can the synthesis of nonprotein substances such as carbohydrates or steroids be under genetic control? 6). Explain the difference between compact and spongy bone, and describe their spatial relationship to each other. 7). Contrast the actions of acetylcholine (ACh), GABA and norepinephrine at their respective synapses. 8). Compare and contrast the composition and locations of gray and white matter in the spinal cord vs. the brain.

Global regulators are proteins that can repress or activate the expression of large numbers of genes...

Global regulators are proteins that can repress or activate the expression of large numbers of genes in an organism. A recent report describes structural studies on the anti-repressor AbbA from the bacterium Bacillus subtilis [Tucker et aL, J. Mol. Biol. (2014)]. This protein has the ability to bind to a second protein, a global repressor named AbrB. These researchers first characterized their recombinant version of AbbA, a 65-residue protein prepared in E.coli cells. (Qa).During the isolation and purification of AbbA,...

We’ve seen in this lab exercise that proteins can be involved in more than one biological...

We’ve seen in this lab exercise that proteins can be involved in more than one biological process or KEGG pathway. Based on what you’ve learned in Cell Biology Lecture or Lab, describe a protein that has a role in multiple processes or pathways. Include in your answer the name of the protein and in which pathway or process it is involved.

Create a diagram of a Small/Medium size Business network Using Computer Network Defense and Defense in...

Create a diagram of a Small/Medium size Business network Using Computer Network Defense and Defense in Depth, Define what a secure network should look like on a modest budget. (Describe your diagram and why you placed your appliances where you chose to place them).

By using the WBS for contruscting a house, students will create a Network Diagram and Critical...

By using the WBS for contruscting a house, students will create a Network Diagram and Critical Path Analysis for the project. A network diagram is essentially a flow chart that includes all of the project elements and how they relate to one another. It depicts the sequence of activities in the project and also shows parallel activities and the links between each activity (PMBOK Guide). When outlined on a network diagram, the critical path is the longest path through the...

Gel filtration chromatography can also be used to determine the molecular mass of proteins. What additional...

Gel filtration chromatography can also be used to determine the molecular mass of proteins. What additional information might this technique provide as compared to SDS-PAGE or ESI-MS (under standard conditions) Please Explain in depth.

How can molecular biology techniques be used to identify genetic disease conditions in fetal or adult...

How can molecular biology techniques be used to identify genetic disease conditions in fetal or adult humans? Provide two examples. basic biotechnology

Using Packet Tracer Create a Network for 3 departments (sales, accounting, HR) in a business. This...

Using Packet Tracer Create a Network for 3 departments (sales, accounting, HR) in a business. This network should observe reduced collisions and minimum broadcasts. Use private network addressing to simulate the network. PLEASE PROVIDE The network diagram, and pings/simulations to demonstrate the correct functioning of the network. I will rate.

Subjects