What happens with blockage of fast sodium channels? Am I correct to say that it increases...

What happens with blockage of fast sodium channels? Am I correct to say that it increases refractory period as phase 0 of fast AP is delayed? Does this mean a decrease in heart rate due to decrease in rate of contractility from decreased spread of depolarization?

Expert Solution

The blockade of fast sodium channels results in suppression/ depression of phse 0 depolarization whereby V_max declines.

This results in prolongation of duration of action potential by decreasing conduction.

There is a decrease in the conductivity and increased refractoriness.

The cells are unable to undergo depolarization (due to blockade of sodium channels) and retard the generation of action potential.

Sydney Mullin answered 2 years ago

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